Exquisite Blood unlocks Lord Zir's hoard chest, the gateway to some of Diablo 4's most powerful Uber Uniques and legendaries that define endgame builds. After defeating Zir in The Ancient's Seat, spend 12 Blood per chest to access his targeted loot pool, maximizing power through gear upgrades that boost damage, survivability, and speed.
Summon and Defeat Zir Efficiently
Travel to The Ancient's Seat in Fractured Peaks and summon Lord Zir for free in post-Season 4 systems—no materials needed for the boss itself. Clear him quickly with a Pit-optimized build, then use your Blood stockpile on the hoard chest immediately after, as it scales with your power level for better drop quality. Repeat runs by farming Blood via Helltides to chain 5-10 clears per session, accelerating gear progression.
Target High-Impact Uber Uniques
Prioritize Zir's drops like Ring of Starless Skies for massive resource generation, Harlequin Crest for defenses and cooldowns, or Ahavarion Spear of Lycander for skill spam across classes. These items provide multiplicative power spikes—equip one to push deeper Pits, farm faster Blood, and loop back for more drops, creating exponential scaling. Focus 80% of your Blood on Zir until you secure 2-3 chase pieces before diversifying to other bosses.
Optimize Loot Through Tempering and Masterworking
Post-Zir drops feed directly into Tempering for affixes like +Ranks to Key Passives and Masterworking for tier 12 upgrades, turning raw legendaries into BiS gear. Use excess Blood runs to gamble on aspects like Banished Lord's for Necro or Ghostwalker for Rogue, then imprint onto Uber bases for hybrid power. This method yields 20-30% DPS gains per full cycle when combined with seasonal mechanics.
Trade and Group for Multipliers
Sell duplicate Zir drops for gold to buy more Blood, sustaining runs without downtime, or join carry groups for shared chests that multiply effective Blood value. In Season 11, group Zir clears drop scaled loot per player, letting you burn 24-36 Blood per session across two chests for double the uniques. This communal approach maximizes power ceiling for solo players lacking top-tier alts.