In Diablo 4, Exquisite Blood is a top-tier crafting material used primarily to summon Uber Lilith, one of the most difficult bosses in the game. It’s also valuable for endgame progression, trading, and min-maxing high-end builds. Since Exquisite Blood only drops in Torment (World Tier IV) and from specific elite encounters, farming it efficiently is key to saving time and maximizing returns. Below are the most efficient endgame routes and methods to help you stockpile this material quickly.
1. Helltide Circuit: Kehjistan and Hawezar Rotation
Helltides are the best large-scale farming events for Exquisite Blood. The elite density, event variety, and Mystery Chests make them ideal for sustained farming sessions.
Route Overview:
-
Start at Iron Wolves Encampment (Kehjistan) and clear all nearby events and elites heading toward Amber Sands.
-
Move northeast toward Omath’s Stronghold, clearing mini-bosses and shrine clusters.
-
Transition into Hawezar’s Rotting Marsh, where elite packs spawn rapidly around shrines and cursed chests.
Why It Works:
-
Constant elite density means consistent Exquisite Blood drops.
-
The region layout allows easy chaining of events and shrines.
-
Frequent Mystery Chests often drop multiple Exquisite Blood in one opening.
Pro Tip: Use Elixirs of Resourcefulness or Precision for extra efficiency, and save enough Aberrant Cinders (250) before moving to a Mystery Chest location.
2. Nightmare Dungeon Circuit: Fast-Reset Farming
Nightmare Dungeons at Tier 50+ are the most consistent and repeatable way to farm Exquisite Blood. The key is choosing layouts that maximize time-to-loot ratio.
Top Picks:
-
Champion’s Demise (Dry Steppes) – short layout, elite-heavy tunnels.
-
Raethwind Wilds (Scosglen) – fast clear speed and linear progression.
-
Wretched Delve (Fractured Peaks) – compact structure, tons of elites.
Farming Strategy:
-
Use Sigil crafting to roll Nightmare Dungeons with modifiers that increase Elite density or Monster Aggression.
-
Skip secondary objectives; focus purely on elite and boss kills.
-
Use portals to reset after the boss kill for back-to-back runs.
Tip: Combine dungeon farming with Glyph XP grinding—two progressions in one efficient loop.
3. World Boss Spawn Rotation
If your schedule aligns with world boss spawns, take advantage of them. Bosses such as Ashava, Avarice, and Wandering Death all have a small but reliable chance to drop Exquisite Blood on Torment difficulty.
Preparation Tips:
-
Check world boss timers regularly—events appear roughly every 3.5 hours.
-
Join public groups for faster kills and increased loot rolls.
-
Stack Magic Find bonuses and Potion Buffs before the encounter.
While not as consistent as dungeon or Helltide farming, world bosses are excellent for quick bursts of high-quality loot.
4. Elite Density Loop: Scosglen Deep Forest Path
For solo players or those avoiding events, open-world elite farming can still be extremely rewarding. The Deep Forests of Scosglen offer some of the highest elite density in the game.
Route Summary:
-
Start at Marowen Waypoint and clear toward the Ancient Reservoir area.
-
Loop through the Wilds of Scosglen, focusing on shrine-dense areas.
-
Reset via teleport once you’ve made a full rotation.
Advantages:
-
Minimal downtime and short travel distances.
-
High shrine frequency boosts kill speed and defense.
-
Great secondary loot, including Forgotten Souls and Fiend Roses.
5. Legion Events and Whisper Integration
Legion Events often spawn waves of elites and mini-bosses, which makes them prime opportunities to collect Exquisite Blood. Combine this with Whispers of the Dead objectives to double up on rewards.
Execution Plan:
-
Track Legion Events on your map and reach the area early.
-
Focus on elite waves and lieutenants, as they have the best drop chances.
-
Complete Whisper objectives nearby to earn Grim Favors simultaneously.
Once you complete 10 Favors, turn them in for cache rewards that may include crafting materials like Exquisite Blood.
6. Efficiency Boosting Tips
To push your farming even further, keep these optimization points in mind:
-
Always play on Torment (World Tier IV)—lower tiers don’t drop Exquisite Blood.
-
Equip high AoE or chain-kill builds like Bone Spear Necromancer or Twisting Blades Rogue for faster clears.
-
Stack Elixir buffs and shrine bonuses to sustain killing momentum.
-
Use Mount routes and portals to minimize downtime between farming zones.
Whether you prefer Helltide rotations, Nightmare Dungeon loops, or open-world elite circuits, efficiency is all about rhythm constant movement, quick resets, and choosing zones with the best elite density. By refining your route and leveraging buffs, you can easily collect enough Exquisite Blood for multiple Uber Lilith summons while raking in high-value loot and experience along the way.