In Path of Exile 2, one of the most exciting discoveries in recent patches is the powerful interaction between the Omen of Sinistral Erasure and a newly introduced skill combination. Players have started calling it the “Infinite Damage Combo” — and for good reason. When used correctly, this setup can deal massive damage in seconds, making it a top-tier build for both new and experienced players. Today, let’s break down exactly how this combo works and how you can use it effectively while managing your PoE 2 items efficiently.

First, the Omen of Sinistral Erasure is a rare and special item that boosts your spell interaction speed and increases the damage output when combined with elemental or chaos-based skills. The trick lies in pairing it with a fast-casting skill that can trigger multiple hits per second. Many players are using this item together with a new ability that scales based on repetition — meaning the faster it repeats, the higher the total damage you deal. By synchronizing these two elements, you can unleash continuous bursts of power that seem almost endless.
Now, to make this setup even stronger, you’ll need the right supporting PoE 2 items. Focus on items that increase your cast speed, critical strike chance, and mana recovery. For example, using a wand or staff with “increased spell damage” modifiers can help multiply the combo’s impact. Don’t forget accessories — rings and amulets that boost elemental or chaos damage are must-haves. Players who buy PoE 2 items with these bonuses often get a big advantage early in the game because they can skip the grind of crafting and jump straight into optimizing their builds.
Here’s a quick tip: to keep the combo running smoothly, you’ll want to manage your mana cost carefully. Equip a belt or flask that restores mana over time. Also, upgrade your skill gems whenever possible — each level adds more potential damage to your combo. Some players even use passive tree nodes that enhance skill repetition or add extra damage per hit, creating a loop of massive explosions.
If you’re not sure where to start collecting gear, websites like u4gm offer reliable options to buy PoE 2 items safely and quickly. This helps you focus more on gameplay and less on farming, especially if you want to test different builds without spending countless hours searching for drops.
The beauty of this combo is that it doesn’t require legendary-tier equipment to start working. With some smart planning, you can build it up step by step, upgrading your PoE 2 items as you go. Once you feel comfortable, try adding damage-boosting jewels or experiment with different skill links to see how far you can push your “infinite damage” potential.
In short, the Omen of Sinistral Erasure combo shows how creative item and skill interactions can change the entire gameplay experience in Path of Exile 2. Whether you’re a beginner or a long-time exile, mastering this build will make your journey through Wraeclast far more exciting and rewarding.